Death from cancer is usually due to metastasis. Fortunately, most cells that escape from a primary tumor fail to form metastases. Identifying reasons for this failure will help development of anti‐metastatic therapies. Intravital videomicroscopy (IVVM) can be used to observe cancer cells injected into live animals. Co‐injected microspheres can be used to assess cell survival. These techniques have been used to show that circulating tumor cells generally arrest in the microcirculation and may extravasate with high efficiency. While many tumor cells (...) may survive in a secondary site, only a small subset form micrometastases and only a subset of these micrometastases persist to form vascularized macrometastases. Furthermore, solitary tumor cells may remain dormant for long periods of time in secondary sites. These findings suggest that metastatic growth and angiogenesis are prime targets for anti‐metastatic therapy. BioEssays 24:885–893, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

It is argued that “human-centredness” will be an important characteristic of systems that learn tasks from human users, as the difficulties in inductive inference rule out learning without human assistance. The aim of “programming by example” is to create systems that learn how to perform tasks from their human users by being shown examples of what is to be done. Just as the user creates a learning environment for the system, so the system provides a teaching opportunity for the user, (...) and emphasis is placed as much on facilitating successful teaching as on incorporating techniques of machine learning. If systems can “learn” repetitive tasks, their users will have the power to decide for themselves which parts of their jobs should be automated, and teach the system how to do them — reducing their dependence on intermediaries such as system designers and programmers.This paper presents principles for programming by example derived from experience in creating four prototype learners: for technical drawing, text editing, office tasks, and robot assembly. A teaching metaphor (a) enables the user to demonstrate a task by performing it manually, (b) helps to explain the learner's limited capabilities in terms of a persona, and (c) allows users to attribute intentionality. Tasks are represented procedurally, and augmented with constraints. Suitable mechanisms for attention focusing are necessary in order to control inductive search. Hidden features of a task should be made explicit so that the learner need not embark on the huge search entailed by hypothesizing missing steps. (shrink)

In this exciting Handbook, Ian Jarvie and Jesús Zamora-Bonilla have put together a wide-ranging and authoritative overview of the main philosophical currents and traditions at work in the social sciences today. Starting with the history of social scientific thought, this Handbook sets out to explore that core fundamentals of social science practice, from issues of ontology and epistemology to issues of practical method. Along the way it investigates such notions as paradigm, empiricism, postmodernism, naturalism, language, agency, power, culture, and causality.

The phrase γρòν δωρ in Anacreontic 33.22 requires more explanation than has until now been offered: the parallel passages cited by M. L. West in his edition , namely Ovid, Ars Am. 3.224, ‘nuda Venus madidas exprimit imbre comas’ and Her. 18.104, ‘madidam…imbre comam’, present the same image, but with quite a different vocabulary, whilst Patricia A. Rosenmeyer regards it only as an example of tautology characteristic of the Anacreontic corpus. But it is by no means unique, and, both for (...) this reason and in the context of the nature of the whole poem, it is capable of further elucidation. (shrink)

The phrase γρòν δωρ in Anacreontic 33.22 requires more explanation than has until now been offered: the parallel passages cited by M. L. West in his edition, namely Ovid, Ars Am. 3.224, ‘nuda Venus madidas exprimit imbre comas’ and Her. 18.104, ‘madidam…imbre comam’, present the same image, but with quite a different vocabulary, whilst Patricia A. Rosenmeyer regards it only as an example of tautology characteristic of the Anacreontic corpus. But it is by no means unique, and, both for this (...) reason and in the context of the nature of the whole poem, it is capable of further elucidation. (shrink)

In this excting Handbook, Jarvie and Bonilla provide a broad and democratic coverage of the many currents in social science.

The concept of social reproduction of sets of advantages and disadvantages together with that of status group, is used to explore the evidence and thinking presented in the Royal Commission on the Blind, the Deaf and Dumb, etc. regarding the education of children with disabilities in 1889. Even though the evidence was ambiguous, models for the education of children with disabilities were laid down. Integration into mainstream elementary schools was recommended for the blind. Recommendations for deaf children were divided in (...) allegiance with belief in the principles of either oralism or signing. The largest group numerically received the least attention in the Commission. The idea of feeble-minded children as a product of social, economic and educational circumstances had its champion but was overwhelmed by the acceptance of the doctrine of the innate characteristics of the child's mind identifiable by medical science. (shrink)

In his article on the early career of Aristophanes, in particular on the relevance of the thiasotai on IG ii2.2343 and the importance of Herakles in the plays of Aristophanes, David Welsh has supported the thesis of Dow, that several of the thiasotai are mentioned by Aristophanes in his plays . He suggests that another of these thiasotai, Lysanias, may be alluded to at Clouds 1162. Here the unusual word λυσανας in the text means ostensibly ‘deliverer’, but Welsh argues that (...) in view of the rarity of the word ‘the spectators would have been put in mind of a contemporary individual…a Lysanias who was known for his filial piety or forensic ability .’. (shrink)

An exploration of the governmental policy, prison works, and its attendant recidivism provides the general opening. The 1944 Education Act is then taken as furnishing the medical model of personal handicap and deficiency which informed special education at an early stage. The Warnock Report's attempt to shift considerations to educational grounds is examined with a particular focus upon the ensuing definition of special needs and its legacy in legislation following the 1981 Act to the present. Foucault's concept of normalisation is (...) the basis for analysis of the normative elements in the main features of the national curriculum and testing. This latter together with aspects of the 1988 Education Reform Act are examined with regard to their impact upon special educational needs. The conclusions are that 'education works' and the rediscovery of the medical model of personal deficiency. (shrink)

The concept of social reproduction of sets of advantages and disadvantages together with that of status group, is used to explore the evidence and thinking presented in the Royal Commission on the Blind, the Deaf and Dumb, etc. regarding the education of children with disabilities in 1889. Even though the evidence was ambiguous, models for the education of children with disabilities were laid down. Integration into mainstream elementary schools was recommended for the blind. Recommendations for deaf children were divided in (...) allegiance with belief in the principles of either oralism or signing. The largest group numerically received the least attention in the Commission. The idea of feeble-minded children as a product of social, economic and educational circumstances had its champion but was overwhelmed by the acceptance of the doctrine of the innate characteristics of the child's mind identifiable by medical science. (shrink)

Dainton and Robinson’s Companion traces lines of descent of analytic philosophy from ancestors. They characterize analytic philosophy as a movement, a tradition, a style, and a commitment to the va...

There is little empirical evidence showing a direct link between a capacity for statistical learning (SL) and proficiency with natural language. Moreover, discussion of the role of SL in language acquisition has seldom focused on literacy development. Our study addressed these issues by investigating the relationship between SL and reading ability in typically developing children and healthy adults. We tested SL using visually presented stimuli within a triplet learning paradigm and examined reading ability by administering the Wide Range Achievement Test (...) (WRAT-4; Wilkinson & Robertson, 2006). A total of 38 typically developing children (mean age of 9;5 years, range 6;4–12;5) and 37 healthy adults (mean age of 21 years, range 18–34) were assessed. In children, SL was significantly related to reading ability. Importantly, this relationship was independent of grade and also age. The adult data, too, revealed that SL was significantly related to reading ability. A regression analysis of the combined child and adult data revealed that SL accounted for a unique amount of variance in reading ability, after age and attention had been taken into consideration. For the first time, this study provides empirical evidence that a capacity for more effective SL is related to higher reading ability in the general population. (shrink)

Aristotle argues for and relies on the view that a constitutive norm prescribing true belief binds all rational subjects. This normativity is peculiar to belief, and derives but is distinct from the epistemic value of true belief, which is grounded in a teleological function that governs even non-rational cognition. Only rational creatures can have beliefs, and Aristotle uses the normative constraint on belief to distinguish it from imagining, its closest non-rational counterpart. This subjection to norms is therefore part of what (...) separates rational from non-rational cognition. (shrink)

We have far less evidence for Aristotle’s reception of Protagoras than we like to think, and the evidence we do have is somewhere we hardly ever look. With one exception, every reference Aristotle makes to the Measure Doctrine—Protagoras’ claim that humans are the ‘measure of all things —concerns the Doctrine as amplified in Plato’s Theaetetus, and the ‘Protagoras’ in question is Plato’s fictional character as fictional. Metaph. I 1, 1053a35–b3 provides the only exception, where Aristotle offers an anomalous reading of (...) the Doctrine incompatible with the others. The chapter interprets I 1, 1053a35–b3 and concludes that Aristotle attributes the anomalous reading to Protagoras himself. The chapter argues further that every other reference to the Doctrine derives from the Theaetetus. Aristotle formulates ‘the theory of Protagoras’ according to Plato’s self-refutation argument, and his argument that it denies the Principle of Non-contradiction includes premisses from Plato’s argument that are out of place in Aristotle’s own. He moreover attributes to ‘Protagoras’ arguments and dialectical demands that the fictional Protagoras makes in his so-called ‘apology’, so his target is specifically a Platonic invention and not the historical person. This leaves only Metaph. I 1 1053a35–b3 to join his six other references to the historical Protagoras, which makes it Aristotle’s only engagement with the Measure Doctrine as the actual view of his predecessor. (shrink)

This paper articulates and defends a novel view of the strict distinction that Aristotle makes between human and non-human mental life. We examine two crucially relevant but overlooked arguments that turn on the human capacity for reasoning and inference (syl/logismos) to reconstruct his view of what makes some cognitive processes rational and how they differ from non-rational counterparts. A creature is rational just in case its occurrent cognitive states exhibit a sequential coherence wherein prior cognitive activity constrains subsequent activity for (...) the sake of attaining truth. Processes are rational, then, in virtue of how constituent states relate to each other, not whether any given state involves some peculiar content or grasps some distinct object. This study aids, but does not exhaust, a systematic examination of the rational soul in Aristotle’s writing, based on (a) the human/animal comparisons through which he often elucidates rational cognitive capacities and (b) the distinctions that he draws between elements of rational cognition and non-rational counterparts in terms of what minimally suffices to distinguish between them. (shrink)

With the rise of the knowledge economy, the knowledge content of goods and services is going up just as their material content is declining. Economic value is increasingly seen to reside in intangible assets, rather than material. This book explores the framework of 'I-Space' - a theoretical approach to the production and distribution of knowledge.

Tigard suggests that the medical community would benefit from continuing to promote notions of individual responsibility and blame in healthcare settings. In particular, he contends that blame will promote systematic improvement, both on the individual and institutional levels, by increasing the likelihood that the blameworthy party will ‘own up’ to his or her mistake and apologise. While we agree that communicating regret and offering a genuine apology are critical steps to take when addressing patient harm, the idea that medical professionals (...) should continue to ‘take the blame’ for medical errors flies in the face of existing science and threatens to do more harm than good. We contrast Dr Tigard’s approach with the current literature on blame to promote an alternative strategy that may help to create lasting change in the face of unfortunate error. (shrink)

Popper holds to the unity of scientific method: any differences between natural and social science are a product of theory, not a pretheoretical premise. Distin guishing instead pure and applied generalizing sciences, Popper focuses on the different role of laws in each. In generalizing social science, our tools are the logic of the situation, including the rationality principle, and unintended conse quences. Situations contain individuals, but also social entities not reducible to individuals: conspiracy theory is the extreme form of individualism. (...) Action in situations has unintended consequences. Both social and natural laws may be required to explain outcomes. The fate of Popper's ideas is a case study in the logic of the situation. Professional philosophers of social science lean toward individualism and a priorism (either intuitionist or rational choice). There are social and political explanations of this outcome, but little critical engagement with Popper's ideas. (shrink)

In this response to Emily Katz’s “Aristotle’s Rejection of Mathematized Metaphysics,” I raise questions about her central interpretive claim that mathematical forms cannot, for Aristotle, appear among first principles of nature. Topics addressed include the notion of priority, especially in the sciences; the relationship between natural change and material realization; and the general nature and scope of mathematical explanations for physical phenomena.

BackgroundThe proper and ethical inclusion of PWLHIV and their young children in research is paramount to ensure valid evidence is generated to optimize treatment and care. Little empirical data exists to inform ethical considerations deemed most critical to these populations. Our study aimed to systematically review the empiric literature regarding ethical considerations for research participation of PWLHIV and their young children.MethodsWe conducted this systematic review in partnership with a medical librarian. A search strategy was designed and performed within the following (...) electronic databases: Ovid MEDLINE, Embase and CINAHL. We screened titles and abstracts using the following inclusion criteria: (1) a study population of PWLHIV or children under 5 years of age; and (2) collection of qualitative or quantitative data regarding ethics of research participation. Excluded were reviews, commentaries, policy statements, clinical care-related ethics concerns, abstracts, case studies, or studies unrelated to HIV research. Studies were appraised for quality, data were extracted, and studies were qualitatively analyzed using a principle-based ethical framework within the Belmont Report.ResultsOf the 7470 titles identified, 538 full-text articles were reviewed for eligibility and only three articles met full criteria for inclusion within this review. While we allowed for inclusion of studies involving young children born to mothers with HIV, only articles focused on PWLHIV were identified. Within the results of these studies, four themes emerged: (1) adequacy of informed consent; (2) consideration of paternal involvement; (3) balancing risks; and (4) access to research and treatment. A strength of this review is that it included perspectives of international research investigators, community leaders, and male partners. However, only two studies collected empiric data from PWLHIV regarding their experiences participating in researchConclusionResearchers and funding agencies should be aware of these considerations and appreciate the value of and critical need for formative research to ensure clinical trials involving PWLHIV promote ethical, well-informed research participation and, ultimately, improve care outcomes. More research is needed to create a comprehensive ethical framework for researchers when conducting studies with PWLHIV. (shrink)

Here we describe how more important findings were obtained in a delirium study by using an informal assessment of mental capacity, and, in those who lacked capacity, obtaining consent later when or if capacity returned or a proxy was found. From a total of 233 patients 23 patients lacked capacity as judged by our informal capacity judgment and 210 did not. Of those who lacked capacity, 13 agreed to enter in the study. Six of them regained capacity later. When these (...) 13 participants were excluded from analysis, significant findings were no longer evident. These results show that by the inclusion of subjects who lacked capacity the results of analyses of the condition from whish they suffer are altered. We suggest that this approach to the study of delirium is more ethical than the usual system of strict exclusion of people who lack capacity to give consent and for whom assent is not available. (shrink)

A robust result in research on the production of grammatical agreement is that speakers are more likely to produce an erroneous verb with phrases such as the key to the cabinets, with a singular noun followed by a plural one, than with phrases such as the keys to the cabinet, where a plural noun is followed by a singular. These asymmetries are thought to reflect core language production processes. Previous accounts have attributed error patterns to a syntactic number feature present (...) on plurals but not singulars. An alternative approach is presented in which a process similar to structural priming contributes to the error asymmetry via speakers' past experiences with related agreement constructions. A corpus analysis and two agreement production studies test this account. The results suggest that agreement production is shaped by statistical learning from past language experience. Implications for accounts of agreement are discussed. (shrink)

Science is not a great way to make money, or these days, even a job. But there are great riches in it, and in this book too. Tim Bradford, 'New Scientist'.

Reading W.K. Clifford’s “The Ethics of Belief” in evidentialist terms is standard. However, evidentialist accounts face several longstanding interpretive issues over the Shipowner Story and Clifford’s Motto. This article defends an evidentialist reading. But what distinguishes it from others is that it interprets “The Ethics of Belief” according to Clifford’s “first principle of natural ethics”, a principle he articulates in prior writings, and which comes down to social trust. I reorient Clifford’s evidentialism by returning to his core moral principle and (...) argue that doing so can establish coherence across Clifford’s writings on ethics and can help resolve the relevant interpretive issues. (shrink)

Descartes convinced himself that the safest way was to ‘begin’ by doubting everything… Genuine doubt does not talk of beginning with doubting. The pragmatist knows that doubt is an art which has to be acquired with difficulty; and his genuine doubts will go much further than those of any Cartesian.In 1906, while ruminating on the reality of God, Peirce considers again Descartes’ attempt to doubt everything. Such a task is the preliminary to Descartes’ project of first philosophy, and that project (...) aims to discover metaphysical truths or the first causes of things. In response to Descartes, Peirce returns to a claim that he had been defending since... (shrink)

Sexually‐selected exaggerated traits tend to be unusually reliable signals of individual condition, as their expression tends to be more sensitive to nutritional history and physiological circumstance than that of other phenotypes. As such, these traits are the foundation for many models of sexual selection and animal communication, such as “handicap” and “good genes” models. Exactly how expression of these traits is linked to the bearer's condition has been a central yet unresolved question, in part because the underlying physiological mechanisms regulating (...) their development have remained largely unknown. Recent discoveries across animals as diverse as deer, beetles, and flies now implicate the widely conserved insulin‐like signaling pathway, as a common physiological mechanism regulating condition‐sensitive structures with extreme growth. This raises the exciting possibility that one highly conserved pathway may underlie the evolution of trait exaggeration in a multitude of sexually‐selected signal traits across the animal kingdom. (shrink)